Diastereodivergent synthesis
WebJul 24, 2014 · Diastereodivergent synthesis of enantioenriched α,β-disubstituted γ-butyrolactones via cooperative N-heterocyclic carbene and Ir catalysis 02 December … WebJun 14, 2024 · Diastereodivergent Synthesis of Chiral 4-Fluoropyrrolidines (exo and exo′) Based on the Cu(II)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition Subarna Jyoti …
Diastereodivergent synthesis
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WebDivergent synthesis. In chemistry a divergent synthesis is a strategy with the aim to improve the efficiency of chemical synthesis. It is often an alternative to convergent … Web1. Introduction The field of N-heterocyclic carbene (NHC) complexes of 3d metals has grown significantly in recent years since the first synthesis of an isolable imidazol-2-ylidene by Arduengo in 1991. 1 Consequently, NHCs have found numerous applications across fields such as catalysis, materials sciences and metallopharmaceuticals. Comprehensive and …
WebJan 17, 2024 · Introduction As different stereoisomers usually display distinct biological activities, precise construction of multiple optically active isomers has always been an attractive but challenging task in organic chemistry and the drug discovery field. 1 Diastereodivergent synthesis, which enables producing diverse diastereomers from … WebJul 2, 2024 · 1,3-Dipolar cycloaddition of azomethine ylides and electron deficient alkenes is widely studied for rapid installation of pyrrolidine frameworks. Despite significant …
WebMar 15, 2024 · Herein, we report a method for dual-metal-catalyzed diastereodivergent coupling of alkoxyallenes with aldimine esters. By carefully selecting the two metals and appropriate chiral ligands, we could synthesize both syn- and anti-β-amino alcohol motifs with high enantioselectivity and diastereoselectivity from the same set of starting materials. WebJan 18, 2024 · A tandem asymmetric catalytic O–H insertion/Barnes–Claisen rearrangement reaction from 4-acyl-1-sulfonyl-1,2,3-triazoles with allylic alcohols is developed for the purpose of synthesizing all possible stereomers of α-aminoketones under mild conditions. It is found that 4-acyl-1-sulfonyl-1,2,3-triazoles not only form rhodium carbenoids with …
WebSep 16, 2024 · However, the stereodivergent synthesis of spirocycles bearing multiple stereocenters remains an unsolved challenge owing to steric hindrance and ring strain. Herein, we report an enantio- and diastereodivergent synthesis of rigid spirocycles through dual-metal-catalyzed [3+2] annulation of oxy π-allyl metallic dipoles with less …
WebDec 1, 2024 · Herein, we report an enantio‐ and diastereodivergent synthesis of rigid spirocycles through dual‐metal‐catalyzed [3+2] annulation of oxy π‐allyl metallic dipoles with less commonly ... bart gaugeWebAs such, the diastereodivergent synthesis of a target spirocyclic compound not only results in the formation of spirocyclic compounds with varied biological activities but also … svastica nejiWeb李青竹，博士研究生，研究员，硕士生导师。兼职情况：《中国抗生素杂志》青年编委最高学历毕业院校及专业： 2016年6月毕业于四川大学药物化学所属学科：药物化学研究方向：有机小分子催化方法学探索；手性杂环类药骨架的高效构建；绿色高效可控的自由基转化策略研究获奖或荣誉称号：成都 ... bart gatz pain managementWebNov 17, 2016 · However, the diastereodivergent synthesis is a great challenge because the formation of one of the diastereomers is … svastica pdfWebTotal Synthesis of the Fungal Metabolite Trienylfuranol A through Nucleophilic Diastereodivergent Additions to Oxocarbenium Ions bart giamatti baseball poemWebFeb 13, 2024 · Importantly, switchable diastereodivergent synthesis could be achieved by tuning the chiral bisphosphine ligands, which led to the construction of a broad spectrum of fused tetrahydroquinoline architectures with moderate to excellent enantioselectivity. Ligand control even enabled effective access to regiodivergent azetidine or chemodivergent ... svastica pcWebDec 18, 2024 · A novel palladium-mediated carbonylogous 1,4-dipole was developed by in situ deprotonation. By using our own-developed C2-unsymmetric phosphoramidite as supporting ligand, this dipole was applied to the asymmetric synthesis of chiral cyclohexanones via a catalytic [4+2] cycloaddition. Electron-deficient allylic carbonate … svastica romani