WebbAll studies showed that a hydrogen bond with His524 for an agonist and with Thr347 for an antagonist was created, exactly as in the case of estradiol and 4-OH-tamoxifen, … WebbNM_020631.6(PLEKHG5):c.1569C>T (p.His523_His524=) AND multiple conditions Clinical significance: Likely benign (Last evaluated: Jul 7, 2024) Review status: 1 star out of maximum of 4 stars
Leif Eriksson Göteborgs universitet
Webb6 jan. 2024 · His524 adopts a spectrum of conformations depending on the steric and electronic properties of the ligand. When ERα is bound to a ligand in which a phenol … Webb30 apr. 2024 · Thus, we speculated that the HIE model of His524 might be used in the two previous docking calculations (although the authors did not unambiguously point out the protonation state of His524). However, for the HIP model, we observed that the protonated His524 had the stronger capacity to attract the acid tails of PFOA and PFOS than … the other miss bridgerton read online pdf
Conformational dynamics of the estrogen receptor alpha
Webb15 mars 2024 · His524, Arg394 and Glu353 formed intermolecular hydrogen bonds with 14 chemicals, which were the important residues in flavonoids-ERα interactions. Also, … Webb21 juli 2006 · The ab initio fragment molecular orbital calculations were performed for molecular interactions of the whole estrogen receptor (ER) ligand-binding domain with a natural ligand, 17β-estradiol (EST). The interaction energies of the ligand at the residue level were calculated using HF and MP2 methods with several basis sets. The charge … Webb7 apr. 2012 · Both His524 and Leu525 are geometrically in contact with the agonist ligands in the crystal structures, and are furthermore located on H11, which is closely linked to the essential helix 12. shudder plan costs