Web後期促進複合体. 後期促進複合体 （こうきそくしんふくごうたい、 英: anaphase-promoting complex ）は、 細胞周期 タンパク質に26S プロテアソーム による分解の目印を付けるE3 ユビキチンリガーゼ である。. サイクロソーム（cyclosome）とも呼ばれ、 APC/C と略さ ... WebThe anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps control chromosome separation and exit from mitosis in many different kinds of organisms, including yeast, flies, worms, and humans. This review represents a new perspective on the connection between APC/C subunit mutations and cancer.
SAMBA, a plant-specific anaphase-promoting complex/cyclosome …
WebJul 1, 2006 · The anaphase-promoting complex/cyclosome (APC/C) is a protein-ubiquitin ligase (E3) that initiates the final events of mitosis by catalyzing the ubiquitination and proteasomal destruction of ... WebAug 29, 2010 · The E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) attached to the activator protein Cdh1 plays a crucial role in controlling G1- to S-phase … dr salima manji
GIGAS CELL1, a Novel Negative Regulator of the Anaphase-Promoting …
Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. Other … See more The APC/C's main function is to trigger the transition from metaphase to anaphase by tagging specific proteins for degradation. The three major targets for degradation by the APC/C are securin and S and M cyclins. Securin releases See more There is not a vast amount of extensive investigation on APC/C subunits, which serve mostly as adaptors. Studies of APC subunits are mainly … See more As metaphase begins, the spindle checkpoint inhibits the APC/C until all sister-kinetochores are attached to opposite poles of the mitotic spindle, a process known as … See more APC/C inactivation during early stages of the cell cycle is partially achieved by the protein Emi1. Initial experiments have shown that addition of Emi1 to Xenopus cycling extracts can … See more APC/C substrates have recognition amino acid sequences that enable the APC/C to identify them. The most common sequence is known … See more Upon completion of mitosis, it is important that cells (except for embryonic ones) go through a growth period, known as G1 phase, to grow and produce factors necessary for the next cell cycle. Entry into another round of mitosis is prevented by inhibiting Cdk … See more • Motifs Targeted by APC/C See more WebMay 15, 2024 · The anaphase-promoting complex/cyclosome (APC/C) and its co-activators Cdc20 and Cdh1 represent an important checkpoint in mitosis. Here, the role of the APC/C and its co-activators is examined in ... WebMar 18, 2024 · A study now shows that in the absence of piRNA loading, human PIWIL1 promotes pancreatic cancer metastasis by acting as a co-activator of the anaphase-promoting complex/cyclosome (APC/C) to ... dr. salil manek spokane wa