WebJul 16, 2024 · About: Thiotepa (Thioplex®, Tepadina®) Thiotepa damages cancer cells through a process called alkylation. Alkylation damages the DNA of cells, which prevents them from dividing, and causes them to die. Since cancer cells, in general, divide faster and with less error-correcting than healthy cells, cancer cells are more sensitive to this damage. Web0.4 mg/kg (increased by 0.1 mg/kg/dose until response observed) monthly or. 0.03-0.1 mg/kg/day continuously. Reduce initial dose if administered within 4 weeks after a full …
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WebThiotepa is an alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas. ... Chlorambucil: The risk or severity of adverse effects can be increased when Chlorambucil is combined with Thiotepa. WebChlorambucil is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell cycle non-specific. There are several types of alkylating agents. Mustard gas derivatives: Mechlorethamine, Cyclophosphamide, Chlorambucil, Melphalan, and Ifosfamide. Ethylenimines: Thiotepa and ... towika knives ireland
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WebSome examples of alkylating agents are nitrogen mustards (chlorambucil and cyclophosphamide), cisplatin, nitrosoureas (carmustine, lomustine, and semustine), alkylsulfonates (busulfan), ethyleneimines (thiotepa), and triazines (dacarbazine). The types of molecular changes induced by alkylating agents include cross-linking between strands … WebSep 17, 2024 · A composition according to the present invention can very effectively prevent, ameliorate, or treat gastric cancer, specifically intractable gastric cancer, by screening a subject with suitable generic characteristics for a drug capable of suppressing caveolin-1-mediated endocytosis, and administering the drug into the screened subject. WebThiotepa: Irritation and rarely hemorrhagic cystitis: Intravesical: Doxorubicin: Reversible hemorrhagic cystitis in 20 to 30%: ... Intravesical: Fludarabine: Rare hemorrhagic cystitis : Chlorambucil: Rare cases of sterile cystitis : Cabazitaxel: Hemorrhagic cystitis in 17%; severe (grade 3 or 4) in 2 to 3% . Dacarbazine, temozolomide: Rare ... powerbank kfz starthilfe dino